Paget's Disease of Bone
Condition causing abnormal bone remodelling, leading to enlarged and weakened bones. Treatment can control the disease and prevent complications.
Last medically reviewed by Dr Leena Das: March 2026
Paget's disease of bone is a condition where the normal process of bone renewal becomes disrupted, leading to bones that are larger, weaker, and more prone to fracture. It most commonly affects the pelvis, spine, skull, and long bones of the legs.
The condition affects approximately 1-2% of people over 55 in the UK and is more common in men. Many people with Paget's disease have no symptoms and the condition is discovered incidentally through blood tests or X-rays taken for other reasons.
When symptoms do occur, they may include bone pain (often a deep, aching pain), joint pain if affected bone is near a joint, bone deformity (such as bowing of the legs), hearing loss if the skull is affected, and increased warmth over affected bones.
Dr Das diagnoses Paget's disease through blood tests (alkaline phosphatase is typically elevated), X-rays, and bone scans. Treatment with bisphosphonates (typically zoledronic acid) is highly effective at controlling the disease and can provide long-lasting remission. Not all patients require treatment — Dr Das will advise based on the location and extent of disease and the presence of symptoms.
Symptoms
- •Bone pain (deep, aching)
- •Joint pain near affected bones
- •Bone deformity
- •Hearing loss
- •Warmth over affected bones
- •Often no symptoms (discovered incidentally)
Treatment Options
- ✓Bisphosphonates (zoledronic acid)
- ✓Pain management
- ✓Monitoring of alkaline phosphatase levels
- ✓Physiotherapy
- ✓Surgical intervention if needed for complications
Frequently Asked Questions
Is Paget's disease serious?
For many people, Paget's disease causes few or no symptoms and does not significantly affect daily life. However, it can cause pain, deformity, and complications such as fractures or arthritis in nearby joints. Treatment is highly effective when needed.
How is Paget's disease treated?
The main treatment is bisphosphonate medication, typically a single infusion of zoledronic acid, which can control the disease for several years. Dr Das will monitor your response and advise on any further treatment.
Can Paget's disease affect any bone?
It most commonly affects the pelvis, spine, skull, and legs, but can affect any bone. It typically involves one or a few bones rather than the entire skeleton.
Expert Paget's Disease of Bone Care
Book a private consultation with Dr Leena Das. Self-referral accepted — no GP referral needed.
Book Appointment — From £225